Research & Publications
Grouped by research area — click a heading to collapse it. For citation metrics and the most recent indexing, see my Google Scholar profile.
I. Statistical Methodology
Peer-reviewed journal articles
- Penalized principal machines for sufficient dimension reduction and its efficient computation
- psvmSDR: An R Package for a Unified Algorithm for Sufficient Dimension Reduction via Principal Machines
- A least distance estimator for a multivariate regression model using deep neural networks
- Simultaneous estimation and variable selection for a non-crossing multiple quantile regression using deep neural network
- Concise overview of principal support vector machine
- Penalized least distance estimator in the multivariate regression model
- The LSTM-based algorithm for detecting vessel abnormal behaviors
- A comparison study of inverse censoring probability weighting in censored regression
Peer-reviewed conference proceeding
- Privacy-preserving face redaction using crowdsourcing
Book
- Introduction to Statistics and Its Application with R
Manuscripts under review and revision
- spaCraft: Calibrated power analysis and sample-size planning for multi-sample spatial transcriptomics
- Penalized deep support vector machines for nonlinear classification and variable selection
- SpaDesign: Simulation-based framework for determining sequencing depth for spatial transcriptomics experiments Co-first author
- Circular data analysis in spatial omics
- VeteranST: Transcriptional Variability and Gene Co-Expression Analysis in Spatial Transcriptomics
- SpatialNetworkMediation: a framework for mediation analysis of spatial transcriptomic data
- CellPacman: An interpretable machine-learning pipeline for phenotypic discovery and dose–response characterization of Cell Painting assays Co-first author
- A unified framework of penalized deep composite quantile regression for simultaneous function estimation and variable selection
II. Biomedical and Collaborative Research
Peer-reviewed conference abstracts
- Biomarker-driven exploratory clustering of cytokine and hematologic profiles in a Phase II trial of metronomic chemotherapy plus cemiplimab in R/M HNSCCContribution: Lead biostatistician; conducted UMAP-HDBSCAN clustering, cluster characterization, and biomarker-survival association analyses.
- Cytokine analysis in a Phase II trial of metronomic carboplatin/paclitaxel plus cemiplimab for recurrent/metastatic head and neck squamous cell carcinomaContribution: Lead biostatistician; conducted longitudinal cytokine analyses, response-group comparisons, multiplicity-adjusted testing, and survival association analyses.
- Safety and immunomodulatory effects of siltuximab prophylaxis prior to standard-of-care CD19-directed chimeric antigen receptor T-cell therapy for B-cell lymphomas: Final Phase I trial resultsContribution: Lead biostatistician; conducted time-matched cohort comparisons of spectral flow cytometry, cytokine, clinical-response, and survival data.
- Decoding immune suppression in Merkel cell carcinoma through integrated spatial transcriptomics and multiplex proteomicsContribution: Lead biostatistician; integrated and analyzed spatial transcriptomics and multiplex proteomics data.
Clinical manuscripts under review
- Phase I study assessing the safety and immunomodulatory effects of prophylactic siltuximab prior to standard-of-care CD19-directed chimeric antigen receptor therapy Co-first authorContribution: Lead statistician; performed all statistical analyses, including linear mixed-effects models, survival analysis, multivariate regression, and longitudinal data analysis.
- Clinical and genomic predictors of hyperprogression in recurrent/metastatic head and neck cancer: Discovery and validation Co-first authorContribution: Lead biostatistician responsible for conceptualization and all statistical analyses.
In preparation
- Sparse and Stable Response-Sufficient Representations for Single-Cell Omics
- Spatial Principal Machines for Sparse Sufficient Dimension Reduction
* Corresponding author. † Equal contribution. Ellipses indicate omitted coauthors.